Albus Suspension

Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production. Ultimately leading to immobilization and death of the parasite.A
It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules.A
As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted.A
Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased adenosine triphosphate (ATP) production, which is the energy required for the survival of the helminth.