Cisplatin Injections By Apollo Life Sciences Pvt. Ltd.

Category: Anticancer
Each vial contains:-
Cisplatin- 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
Cisplatin Injections is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with a SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.
Composition :10mg/20ml, 50mg/100ml
Indication :Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer.
Dosage :-Admin by slow infusion 10-60 mg or as required.
Contra Indications :-Pregnancy, lactation hypersensitivity, renal impairment.
Special Precautions :-Maintain good hydration. Shock like state sometimes occurs during i.v. infusion,. Monitor haematological, neurological status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia.
Paediatrics :Not usually prescribed. The risk of hearing loss is increased.
Pregnancy :-Not usually prescribed.
Lactation :-Not advised.
Elderly :-Reduced dose may be necessary.
Side Effects :-Nausea, vomiting, Tinnitus, deafness, neuropathy, nephrotoxicity, electrolyte imbalance.
Drug Interactions :-Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs.Synergistic with 5-fluorouracil and etoposide.
Purity:Not less than 99%