Golden And Yellow He4 Human Epididymis Protein 4

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HE4 (Human Epididymis Protein 4)
Compatible instrument: Luminex 200,TESMI F4000 .
Reference Value: Females: < or =140 pmol/L
Tellgen also provide following Tumor markers and Tumor Marker control :
CA125
CA153
CA24-2
CYFRA21-1
AFP
CEA
CEA
total PSA
free PSA
free-I -hCG
CA19-9
NSE
SCCA
CA72-4
CA50
HE4
ProGRP
PGI/PGII
Control 1
Control 2
Control 3

Increase in human epididymis protein 4 (HE4) suggests recurrence or disease progression, while a decrease suggests therapeutic response. A change in serum HE4 concentration of > or =20% is considered significant.

Human epididymis protein 4 (HE4) belongs to the family of whey acidic four-disulfide core proteins. Currently, the biologic function of HE4 is unknown.

HE4 has been shown to be overexpressed in 93% of serous, 100% of endometrioid, and 50% of clear cell ovarian carcinomas. In a study of 233 patients with a pelvic mass, including 67 with epithelial ovarian cancer, HE4 had a higher sensitivity for ovarian cancer detection than cancer antigen 125 (CA 125), 72.9% versus 43.3%, respectively, at a specificity of 95%. Researchers also found HE4 to be elevated in more than half of the ovarian cancer patients who did not have elevated CA 125 levels; therefore, the combination of markers provided slightly improved cancer diagnostic sensitivity for the detection of ovarian cancer.