N-cyclopropylpiperazine (Cas 20327-23-5)

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What is N-cyclopropylpiperazine?
N-cyclopropylpiperazine is a pharmaceutical intermediate.

Application of N-cyclopropylpiperazine

Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. N-cyclopropylpiperazine is involved in the production process in the form of 1-Cyclopropylpiperazine dihydrochloride.
N-cyclopropylpiperazine can also be applied in an alternative synthesis process of an antibacterial 1-cyclopropyl-6-fluoro-1,4- dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid of the formula ##STR1##. In the process, branched or straight-chain propyl or butyl is optionally substituted by hydroxy or methoxy, unsubstituted tert.-butyl, 2-methylthioethyl, trifluoromethylthiomethyl, 2-trifluoromethylthioethyl, and cycloalkyl with 3 to 6 carbon atoms. Besides, cycloalkenyl having 5 to 6 carbon atoms is optionally substituted by hydroxyl, 1,1-dioxidotetrahydrothiophen-3-yl, cyclopropylmethyl, 1-phenethyl, and furylmethyl. Moreover, allyl or propargyl is optionally substituted by phenyl and their pharmaceutically usable hydrates, acid addition salts, metal and guanidinium salts and prodrug forms.