Syloid Grade: Medicine Grade

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SYLOID 244 FP Silica
Silica Excipient for Pharmaceutical Applications
High Efficiency
SYLOID 244FP silica is highly efficient in many pharmaceutical applications due to its unique particle structure and morphology. It has a highly developed network of pores
that provide access to the ultra high surface area which defines its performance. The result is a product
Which is:
Easy to incorporate providing more uniform dispersion of actives and improved content uniformity
High in adsorptive capacity both for hydrophilic and hydrophobic compounds
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Applications
Glidant
Tabletting Aid
Carrier for Active Ingredients
Thickening, Gelation, and Suspension
Moisture Scavenger

PROPERTY BENEFIT
High internal porosity and surface area
High efficiency for lower costs
High adsorptive capacity Carry higher level of actives/ reduced level of inactives
Low to moderate density for lower dust
Cleaner work areas and less chance of cross contamination
Controlled particle size distribution
More uniform blending resulting in improved content uniformity Glidant
SYLOID 244FP silica should be incorporated in your formulation at levels from 0.25-1.0% to achieve a free flowing powder that will not stick to the walls of your transfer system, tabletting and other equipment. Uniform powder flow is critical to achieving a consistent
product dosage, whether the product is a capsule, tablet or other oral dosage form of pharmaceutical. The adsorptive properties of SYLOID 244FP silica, along with its ease of
incorporation, make it more effective than other types of glidants used in pharmaceuticals.

Tabletting
SYLOID 244FP silica incorporated into your powder during the granulation process ensures uniform flow through your equipment. This results in higher consistency
during the tabletting process and improvement in the following

Parameters:
Content uniformity
Structural stability
Reduced friability and improved hardness
Resistance to capping, lamination and sticking
Controlled drug release rate During the compression cycle of the tabletting process, liquid ingredients can be forced to the surface or even caused to exude from the tablet. The large internal porosity of SYLOID 244FP silica provides greater capacity for any liquid ingredients that may be included in your formulation, which can prevent the occurrence of the above problems.